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Research in Organic Chemistry and Chemical Biology
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GPCR

Structural and functional diversity among agonist-bound states of the GLP-1 receptor

Posted on June 27, 2022

Structural and functional diversity among agonist-bound states of the GLP-1 receptor

File: Structural-and-functional-diversity-s41589-021-00945-w.pdf

β‐Arrestin-Biased Agonists of the GLP‐1 Receptor from β‐Amino Acid Residue Incorporation into GLP‐1 Analogues

Posted on August 10, 2020

β‐Arrestin-Biased Agonists of the GLP‐1 Receptor from β‐Amino Acid Residue Incorporation into GLP‐1 Analogues

File: Hager-biased-ag-JACS-16.pdf

Backbone modification of a polypeptide drug alters duration of action in vivo

Posted on August 10, 2020

Backbone modification of a polypeptide drug alters duration of action in vivo

File: Cheloha-PTH-NBT-14.pdf

Receptor selectivity from minimal backbone modification of a polypeptide agonist

Posted on August 10, 2020

Receptor selectivity from minimal backbone modification of a polypeptide agonist

File: Liu-Shi-R1-vs.-R2-18.pdf
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