Many host defense peptides (HDPs) rely on the global amphiphilicity for their antimicrobial activities. As a result, the importance of amino acid sequence and secondary structures forantibacterial activities of HDPs are lessened. This enables the possibility of using synthetic polymers as HDP mimics for antimicrobial applications.
Studying structure-activity relationships for nylon-3 polymer subunits enables the design of polymers with maximum potency against pathogenic bacteria and minimum toxicity against human cells. Such properties enable the application of nylon-3 polymers as potential therapeutics for bacterial infections.
For antimicrobial agents, targeting against specific types of microbes could elevate the therapeutic values. We seek to incorporate binding moieties for certain pathogens to improve the organism specificity of nylon-3 polymers.
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