We are broadly interested in developing new types of organic molecules that display useful functions.  In addition, we seek to understand how proteins, the most diverse class of biomolecules, perform their natural functions.  Our efforts require a wide range of experimental tools, including asymmetric organic synthesis, high-resolution NMR and crystallographic analysis of molecular structure, protein expression and biochemical assays.

New Foldamers and Foldamer
Building Blocks

GPCR Modulation

Polypeptide Structure
and Stability

Inhibiting Protein-Protein

Foldamer Catalysis

Bioactive Nylon-3

Beta Sheets

Measuring Modulation of the 
Hydrophobic Force with AFM

Backbone Thioester