Mimicry of Antimicrobial Host-Defense Peptides
Top row: When designing a host-defense peptide (HDP) mimic, the most common approach involves designing a globally amphiphilic helix. We show, with this nylon-3 polymer system (middle left), that a globally amphiphilic, irregular structure can also act as an effective HDP mimic.
Right: Activity as a function of percent cationic subunit (y) in polymers 3y. For polymer 363, MHC/MIC = 32, demonstrating substantial selectivity for bacteria over eukaryotic cells.
Bottom left: Activity of polymer 360 compared to that of three widely-studied HDP and an artificial mutant known to be more active than natural magainin.1
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