Research

We are broadly interested in developing new types of organic molecules that display useful functions.  In addition, we seek to understand how proteins, the most diverse class of biomolecules, perform their natural functions.  Our efforts require a wide range of experimental tools, including asymmetric organic synthesis, high-resolution NMR and crystallographic analysis of molecular structure, protein expression and biochemical assays.


New Foldamers and Foldamer
Building Blocks


GPCR Modulation
 


Polypeptide Structure
and Stability


Inhibiting Protein-Protein
Interactions

 
Foldamer Catalysis
 


Bioactive Nylon-3
Polymers


Beta Sheets
 


Measuring Modulation of the 
Hydrophobic Force with AFM


Backbone Thioester
Exchange